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It is not a substitute for professional care. Likewise, HPV infection is also responsible for causing cervical, vaginal, vulvar, oropharyngeal, penile and rectal cancers. Initiation of anti-retroviral therapy in the s greatly reduced the AIDS-related death rate and improved survival. HPV infection can lead to the development of anal precancer which, if remains undetected or not adequately treated, may lead to anal cancer. How do we start managing our patients using the best available evidence. We found that HIV-infected gay and bisexual men who are 38 years or older should be treated using surgical treatment of ablation either infrared coagulation or electrocautery , and that HPV vaccination should be administered at the time of surgery.

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Some in the medical community have identified anal cancer as the next big crisis among HIV-infected gay and bisexual men. We tracked the number of individuals who developed anal cancer and then estimated their risk of death from anal cancer. We do not yet know how best to manage anal precancer also known as high-grade squamous intraepithelial lesions so that anal cancer could be prevented. We have cross-posted it with their permission. Using a mathematical model, we simulated the life course of , hypothetical HIV-positive men who have sex with men MSM who were 27 years or older and were diagnosed with high-grade squamous intraepithelial lesions.

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We have cross-posted it with their permission. We then estimated above outcomes by patient age. In our model, we compared four different management strategies. If it remains undetected, untreated or inadequately treated, this precancer can progress to anal cancer.

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Description: Advertisement The content on this page is free of advertiser influence and was produced by our editorial team. Using a mathematical model, we simulated the life course of , hypothetical HIV-positive men who have sex with men MSM who were 27 years or older and were diagnosed with high-grade squamous intraepithelial lesions. Likewise, HPV infection is also responsible for causing cervical, vaginal, vulvar, oropharyngeal, penile and rectal cancers. Be careful when providing personal information. In the absence of national screening recommendations, more than 50 percent of these individuals will be diagnosed at stage III or IV, when five-year survival is less than 40 percent. The model also found that because younger men are more likely to be cured of their precancer without intervention, patients younger than 29 should not be treated and those between 29 and 38 years old should be actively monitored watch-and-wait approach in order to prevent treatment-related inconvenience and morbidity that might affect their quality of life. The American Cancer Society estimates there will be 8, new anal cancer cases in
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